Endocrine Control of Gastrointestinal Function
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Endocrine Control of Gastrointestinal Function. Jack L. Leonard 2004. GI Hormones. Candidate Hormones. Neurocrines. Volume Secreted during first 2 hrs. 150. total. 100. 25. cephalic. gastric. 50. total. 20. intestinal. cephalic. 15. Volume (ml/15 min). 10. gastric. 5.

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Endocrine Control of Gastrointestinal Function

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Endocrine control of gastrointestinal function

Endocrine Control of Gastrointestinal Function

Jack L. Leonard 2004


Endocrine control of gastrointestinal function

GI Hormones


Endocrine control of gastrointestinal function

Candidate Hormones


Endocrine control of gastrointestinal function

Neurocrines


Endocrine control of gastrointestinal function

Volume Secreted

during first 2 hrs

150

total

100

25

cephalic

gastric

50

total

20

intestinal

cephalic

15

Volume (ml/15min)

10

gastric

5

intestinal

1

2

3

4

Hours

Fed meat

The Three Phases of Acid Secretion


Endocrine control of gastrointestinal function

+

sight, smell

taste, chewing

swallowing

conditioned reflex

Acetylcholine

Bombesin

-

+

+

-

Somatostatin

+

gastrin

H+

Cephalic Phase

Vagal nucleus

Somatostatin

cell

G-cell

Oxyntic

cell


Endocrine control of gastrointestinal function

local

reflex

acetylcholine

Stomach

distention

Vago-

vagal

reflex

gastrin

bombesin

Peptides

Amino

acids

Protein

digestion

acetylcholine

H+

Gastric Phase


Endocrine control of gastrointestinal function

Intestinal

G Cell

Gastrin

Protein

Digestion

products

Intestinal

Endocrine

Cell

Entero-

oxyntin

H+

Absorbed amino acids

Intestinal Phase


Endocrine control of gastrointestinal function

Factors Regulating Acid Secretion


Endocrine control of gastrointestinal function

Factors Regulating Acid Secretion

Conditioned stimuli

Smell, taste

Chewing

Swallowing

hypoglycemia

Vagus nerve

Gastrin

G cell

H20 &

HCO3-

AcH

AcH

Acinar cells

Duct cells

Enzymes

Gastrin


Endocrine control of gastrointestinal function

Vagus nerve

(vagovagal reflex)

Parietal cell

Fat

Protein

H+

E cells

CCK

Peptides + Amino acids

Fat

S cells

H+

Secretin

Duct

cells

H20 &

HCO3-

Acinar

cells

AcH

AcH

Enzymes

Secretin

CCK

Factors Regulating Acid Secretion (cont)


Endocrine control of gastrointestinal function

Pre-Prandial

Pancreas

Post-Prandial

Monitor peptide

Food Protein

Chymotrypsin

Trypsin

Small intestine

CCK

Pancreatic Enzyme Secretion


Endocrine control of gastrointestinal function

Gut – Insulin Secretion

Neural reflexes

Intestinal dose

Oral dose

40

100

Insulin (mU/ml

Insulin (mU/ml

50

20

0

0

4

8

40

1

20

min

min

10% glucose

10% glucose

100

100

0

0

5 min


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