Developmental Pharmacokinetics of Diclofenac for Acute Pain. Standing JF , Howard RF, Johnston A, Savage I, Wong ICK. Diclofenac. NSAID pKa ~ 4 Oral F (unchanged) = 60% Protein binding > 99.7% (Davies 1997) Linear PK between 50 and 150mg (Lau 1989)
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Standing JF, Howard RF, Johnston A, Savage I, Wong ICK.
NNT for 50% pain relief
Diclofenac dose (mg)
In children: (Romsing 1997)
Predict a paediatric dose which gives a similar AUC to 50mg in adults
Graphs Showing Raw Plots of Diclofenac Serum Concentration Versus Time for Eight Adult Volunteers
Time (hr)Raw Data
Geometric mean standardised CL values:
Best dose = 1mg/kg:
Paediatric AUC: Adult AUC Ratio
1-3 years: 1.00
4-6 years: 1.08
7-12 years: 1.18
Jeff Rothwell, Rosemont Pharmaceuticals
Hussain Mulla & Brian Anderson
Anaesthetic and nursing staff at GOSH
Patients who took part
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Extra slides Versus Time for Eight Adult Volunteers
Pooled DV vs IPRED
Paediatric DV vs IPRED