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interleukin 1, alpha

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.

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interleukin 1, alpha

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  1. IL1A interleukin 1, alpha BackgroundThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. SynonymsBAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; ilia; Interleukin 1 alpha precursor; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Prointerleukin 1 alpha; IL1-ALPHA Recombinant Proteins Cell & Tissue Lysates GMP Proteins Protein Reference Standard Cat.# Product name Source (Host) Species IL1A-2036H Recombinant Human IL1A Protein, His-tagged HEK293 Human His +Inquiry IL1A-577R Recombinant Rhesus Macaque IL1A Protein (113-271 aa), His-SUMO-tagged E. coli Rhesus Macaque IL1A-4318C Recombinant Caprine IL1A Protein Yeast +Inquiry IL1A-5432P Recombinant Pig Interleukin 1, Alpha +Inquiry IL1A-131H Recombinant Human IL1A protein E. coli Human IL1A-14166H Recombinant Human IL1A, GST-tagged GST +Inquiry IL1A-155H Recombinant Human IL1A, None tagged N/A+Inquiry Il1A-26382H Recombinant Human Il1A, HIgG1 Fc-tagged, mutant Human Fc +Inquiry Il1A-26682H Recombinant Human Il1A, HIgG1 Fc-tagged Human Fc +Inquiry IL1A-36682H Recombinant Human IL1A, MIgG2a Fc-tagged CHO Human Fc +Inquiry IL1A-501H Recombinant human IL1A HEK293 IL1A-625H Recombinant Human IL1A protein, His & T7-tagged Human His/T7 +Inquiry TagPrice His-SUMO +Inquiry Caprine E. coli Pig N/A +Inquiry E. coli Human HEK293 Human CHO CHO Human +Inquiry E. coli

  2. Il1a-306M Recombinant Mouse Il1a, None taggedE. coli Mouse N/A +Inquiry Il1a-545M Recombinant Mouse Il1a Il1a-627M Recombinant Mouse Il1a protein, His & T7-tagged E. coli Mouse His/T7 +Inquiry IL1a-640M Recombinant Mouse interleukin 1, alpha, His-tagged Mouse His +Inquiry IL1A-8134M Recombinant Mouse IL1A Protein Mammalian Cells His +Inquiry IL1a-92M Recombinant Mouse IL-1 alphaYeast IL1A-3032R Recombinant Rat IL1A Protein Mammalian Cells +Inquiry Il1a-573R Recombinant Rat Il1a E. coli Rat Il1a-630R Recombinant Rat Il1a protein, His & T7-tagged E. coli RatHis/T7 +Inquiry Il1a-75R Recombinant Rat Il1a protein, His-tagged +Inquiry IL1A-2238R Recombinant Rhesus monkey IL1A Protein, His-tagged Mammalian Cells Rhesus Macaque IL1a-46C Recombinant Canine IL-1 alpha IL1A-620D Recombinant Dog IL1A protein, His-tagged E. coli Dog +Inquiry IL1A-621D Recombinant Dog IL1A protein, His & T7-tagged His/T7 +Inquiry IL1A-631R Recombinant Rabbit IL1A protein, His-tagged His +Inquiry IL1A-207E Recombinant Equine IL1A Yeast Il1a-380C Recombinant Cotton Rat Il1a IL1A-619C Recombinant Cattle IL1A protein, His-tagged His +Inquiry IL1A-622C Recombinant Caprine (Goat) IL1A protein, His-tagged E. coli Caprine (Goat) His +Inquiry IL1A-623H Recombinant Horse IL1A protein, His-tagged His +Inquiry Il1a-624G Recombinant Guinea pig Il1a protein, His & S-tagged Guinea pig His/S +Inquiry IL1A-629P Recombinant Pig IL1A protein, His-tagged E. coli Pig His +Inquiry IL1A-337H Recombinant Human IL1A E. coli Human N/A+Inquiry IL1A-01H Recombinant Human Interleukin-1 alpha +Inquiry IL1A-109H Recombinant Human Interleukin 1, Alpha, Fc Chimera HEK293 Human Fc +Inquiry IL1A-134H Recombinant Human Interleukin 1, Alpha, His-tagged E. coli Mouse +Inquiry E. coli Mouse Mouse +Inquiry RatHis +Inquiry E. coli RatHis His +Inquiry Yeast Canine +Inquiry His E. coli Dog E. coli Rabbit Equine N/A+Inquiry E. coli Cotton Rat +Inquiry E. coli Cattle E. coli Horse E. coli E. coli Human N/A E. coli

  3. Human His +Inquiry Il1a-03M Recombinant Mouse Interleukin-1 Alpha +Inquiry Il1a-92R Recombinant Rat Interleukin 1 Alpha IL1α-81P Recombinant Porcine Interleukin-1 alpha +Inquiry Involved Pathway Il1a involved in several pathways and played different roles in them. We selected most pathways Il1a participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway NamePathway Related Protein MAPK signaling pathwayPAK2B; RPS6KA2; MAPK12A; MAPK8IP2; AKT1; CACNA1B; MAP2K3; CACNB2; ELK1; FGF11A Cytokine-cytokine receptor interactionIL8L1; TNFRSF9; IL6; CCR5; VEGFAA; CXCR6; IFNGR2; MET; Ccl21a; CRFB2 ApoptosisTRAF2; PPP3CB; TICAM1; IRF4; BIRC8; CASP6L2; HRK; CFLAR; CYCSB; BIRC7 Osteoclast differentiationFCGR1A; CALCR; LILRB1; PIK3R5; FCGR1; AKT2; SQSTM1; SIRPG; TEC; TGFBR2 Hematopoietic cell lineageCD14; CD24; ITGAM; TFRC; ITGA4; CD44; Itgam&Itgb2; CD19; IL9R; CD1D Non-alcoholic fatty liver disease (NAFLD)RAC1; NDUFS5; COX8C; IRS2; LEP; CASP8; NDUFB8; PIK3CB; NDUFA4; COX7B Type I diabetes mellitusCD80; HLA-F; HLA-DOA; HLA-C; INS2; HLA-DQA2; FASLG; IL1B; HLA-DQA1; H2-AA Prion diseasesCASP12; SOD1; PRKACA; MAP2K2; PRKACB; C6; HSPA5; C1QC; C7; C8B Salmonella infectionNFKB1; TLR5B; TLR4BB; CDC42; ROCK2A; MAPK14B; KLC2; RAB7B; IL1A; ACTB PertussisMAPK11; CASP7; GM5077; CASP1; CALM4; ITGA5; C1RA; TLR4; ITGAM; MAPK1 LeishmaniasisMAPK13; FCGR2C; PRKCB; NFKBIB; MAP3K7; HLA-DPA1; ELK1; PTGS2; IRAK4; CR1 TuberculosisHLA-DQA2; RIPK2; VDR; ATP6V0C; IFNA17; MRC2; Cd209g; BCL2; CLEC4E; RFXAP MeaslesIFIH1; PIK3R1; Fasl; HSPA2; STAT2; IFNGR1; IL2RA; CCNE1; CD209A; IFNA16 Influenza AIFNAR2; CCL2; IFNB1; TMPRSS13; NLRP3; MAP2K6; IFNA7; IL6; TLR4; HLA-DMB Inflammatory bowel disease (IBD)IFNG; RORC; HLA-DQA2; IFNGR2; IL12B; IFNGR1; IL12RB1; HLA-DMB; IL23; IL17F E. coli Mouse N/A E. coli RatN/A+Inquiry E. coli Pig N/A

  4. Rheumatoid arthritisATP6V1D; IL-8; HLA-DRB4; HLA-DOB; ATP6V1C1; HLA-DRB3; ATP6AP1; LTB; IFNG; ATP6V1E1 Graft-versus-host diseaseHLA-DMA; HLA-DRB3; IL1B; CD86; HLA-DRA; HLA-DRB5; HLA-F; H2-AA; HLA-DOB; HLA-B Protein Function Il1a has several biochemical functions, for example, copper ion binding, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1a itself. We selected most functions Il1a had, and list some proteins which have the same functions with Il1a. You can find most of the proteins on our site. FunctionRelated Protein Function copper ion bindingRelated Protein LOXL2A; IL1A; DBH; LOXL3; LOXL2; ATP7A; MOXD1; ANG; ADNP; SERPINB1A Function cytokine activityRelated Protein IL1F10; BMP8A; GM13288; Il23a; Il12b; IFNPHI1; TNFSF12; IFNA4; GM13285; SECTM1; GPR19 Function interleukin-1 receptor bindingRelated Protein IRAK4; IL37; TLR5; IL1RAP; IL1F10; IRAK1; IL36B; IL36A; IL1A; TRIP6 Function protein bindingRelated Protein COPS7A; RRM2; RBM3; IFT88; IL17RE; TAX1BP3; TICAM1; ARF4; DERL1; CREB5 Interacting Protein Il1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1a.

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