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DIG for Disease Informatics Group RP Deolankar [email protected] Smoking is injurious to health Honorable Mr. Bill Gates revolutionized IT industry Dr. Vijay Bhatkar proved to be supercomputer superman Prof. Kolaskar popularized bioinformatics Now, We are waiting for somebody

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DIG for Disease Informatics Group

RP Deolankar

[email protected]

Smoking is injurious to health





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Now,

We are waiting for somebody

To develop Disease Informatics.

What it is?


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Wealth

Lot of health can be acquired

Because health is wealth

     


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Measure

If

Health is wealth

Then

Fitness is money


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Health Currencies

Say

Fitness dollars

Measures health

F$


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Health Account Scene-1

Expenditure of F$ > Bank Balance in F$

Hardship!!!

= Disease

= Dis + Ease


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TIME BOMB

Health Account Scene-2

Expenditure = Bank Balance

No hardship

No disease but

Predisposed to the disease or

Not really healthy


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Health Account Scene-3

Requirement 1 fitness dollar, Balance 10 fitness dollars

Comfortable, but

Poor than the one having 100 fitness dollars

Disease and health are quantitative concepts

Not quantal

Expressed in relative terms

100F$>10F$>1F$


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Health Account Scene-4

Fakir without a dollar is

much happier than Millionaire

It is human

to make error in defining the disease

We seek, but never find, absolute truth

http://www.wordinfo.info/words/index/info/view_unit/1/?letter=B&spage=3


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Definition of elephant by consensus panel

http://www.wordinfo.info/words/index/info/view_unit/1/?letter=B&spage=3


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Last scene

Man laid 50% in oven and 50% in freezer

Not comfortable, on an average…

Both the gadgets must be tuned for the man

Disease and health are holistic concepts

20

200

-200


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Health means whole

Old. English word. hælþ indicates wholeness

Whole is not finite and difficult to measure

Measurement of fitness is common

We can ask the question “Fit for what?”


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General Holistic definition of health

Health is a state of

Physical, Mental, Social, Emotional and Spiritual wellbeing

and not merely the absence of disease


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Relevance of Health definition

Doctors, Social Workers, Educationists and Spiritual Leaders

contribute to the health of society

and treat diseases


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Limitation of the definition of health

Health is a STATE of… absence of disease

State indicates static

Health is dynamic, it flows, and it is a process


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Adding dynamism

Let us say,

Gaining health is a progression towards wellbeing and

Loosing health is a progression towards disease


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Modern definition of health

Hence, health is a process of gaining of

Physical, Mental, Social, Emotional or Spiritual wellbeing



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Health happens to an individual

Individual = % Wellbeing + % Disease

Loosing the proportion of wellbeing is loosing the health

and proportionally gaining the disease


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Health examination of an individual

It is revealing certain events

in the health history of

an individual


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Point on the curve

Events are sections of

chains in between

‘Wellbeing’ of an individual and ‘Disease’


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Ends of the chains are infinite

Complete ‘wellbeing’ and complete ‘disease’

are difficult to define


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Events

Movement of process

from wellbeing to disease

can thus be judged by events


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Events have depth too

Mild Disease is different than

Severe Disease


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Disease causal chains

Events linked together form the Disease Causal Chain or Web

This chain can be reversed sometimes

http://bmj.bmjjournals.com/cgi/eletters/326/7394/865


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S. No.

Outcome

Back event-1

Back enent-2

Back event-3

Back event-4

Back event-5

4a

DhVDa

VDa

Da

NC-

E

IdIL

UM

In: Ro

UM

4b

DhVDa

VDa

Da

NC-

E

IdIL

UM

In: NRo

UM

Disease Causal Chains can be presented in tabular format

http://bmj.bmjjournals.com/cgi/eletters/328/7443/811#105704


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Database for events

The software should be derived to set aside the combination terms (anatomical + physiopathological) from MeSH database of NCBI. This will provide the database for events occurring in the DiCC.


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Meta-analysis (Systematic Reviews)

Source of priors

It is practice of combining the results of a number of studies that address a set of related research hypotheses

Professor Archibald Leman Cochrane

http://www.cochrane.org/index.htm


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Disease causal chains(DiCC)and Bayes

DiCC has priors and posteriors

It is cake of Bayesian rather than frequentists

Synthesize evidence from multiple sources

Pilot studies

Trials of similar interventions

Subjective judgments about the generalisability of the study's results

http://bmj.bmjjournals.com/cgi/content/full/319/7208/508


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Factors

Certain factors are associated with movement of process

from wellbeing to disease,

which are known as risk factors or protective factors

depending on the direction of movement


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Factors are variables

Most of the time, same factor could be risk or protective

depending on its magnitude and

deviation from homeostasis


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http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Helena Chmura Kraemer


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Human individualhttp://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Disease happens to an individual

We need to understand

What the human individual appears like?

Baba Ramdev


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Model Human = http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Somatic body + Vitality + Mind + Intellect + Bliss


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Human body computer = http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Intellect (Central processing unit) + Self / Ego (Software) +

Memory (Free space, Floppy/ Hard disk) +

Mind/ senses (Program) + Life history (Data)


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Human microbial organshttp://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Gut associated microbiota organ

Vagina associated microbiota organ

Skin associated microbiota organ

Prof. Stig Bengmark


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Study on human (Clinical Research)http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

To understand the disease of an individual

One has to understand the human and

His body computer

His associated organs


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Let us summarisehttp://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1,

What we have discussed about disease till now


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Point no. 1http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Absence of perceptible disease may not be equated to health but lacunae in health is disease


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Point no. 2http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Disease may not be apparent when predisposing events occur


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Point no. 3http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

In short, we all are walking on the path today that may result in disease of tomorrow


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Point no. 4http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

However, bypassing the disease is possible sometimes

So as to avoid the diseases of tomorrow we must act today


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Point no. 5http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Disease predisposing events may not be perceptible easily and may not get attention, however, are real stem of disease causal chain


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Point no.6http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Disease is a relative phenomenon, could mean different to different thinkers, and errors could be rampant in defining the diseases


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Point number 7http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

Disease Informatics Group has to develop health-scoring system


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Point no. 8http://ajp.psychiatryonline.org/cgi/content/full/158/6/848/F1

If disease is present then

Gravity of the disease matters


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